Job Description
Who We Are
Cogent Biosciences is a publicly traded biotechnology company developing real solutions to treat genetically driven diseases. With a focus on rational drug discovery and development, we are leveraging validated biology to advance precision therapies designed to address the true underlying drivers of disease and provide real hope for patients. Cogent's lead therapeutic candidate, bezuclastinib (CGT9486), is a precision kinase inhibitor designed to selectively and potently inhibit the KIT D816V mutation. This mutation is responsible for driving a rare and serious condition called Systemic Mastocytosis (SM), which can severely impact many different tissues and organs in the body. We are also studying CGT9486 to treat advanced gastrointestinal stromal tumors (GIST), which have a strong dependence on oncogenic KIT signaling. We are currently enrolling two Phase 2 clinical trials for patients with SM and a global Phase 3 trial for GIST patients.
Our Team
The Role: We are looking for motivated synthetic organic chemists to help us progress our small molecule drug discovery projects from inception to IND as we build a robust research pipeline.
Responsibilities - Carry out the synthesis, purification, and characterize small molecule drug-like compounds independently
- Collect and interpret data to guide the design and synthesis of analogs in an iterative fashion
- Work closely with medicinal chemists, computational chemists and other project team members in the design and optimization of compounds with improved potency, selectivity, and functional activity against their desired target
- Be the expert in your area of a project and regularly present your ideas in team meetings
- Using your chemistry knowledge, contribute to solving synthetic challenges across projects
- Lead the design, planning, and implementation of laboratory experiments
- Develop hypotheses based on data and design experiments to test these hypotheses
- Contribute ideas to advance projects across our pipeline
- Maintain a high level of familiarity with the current scientific literature
Qualifications - For Sr. Scientist position, a Ph.D. in Organic or Medicinal chemistry; MS/BS with 5+ years of industry experience will be considered
- For Principal Scientist, a Ph.D. in Organic or Medicinal Chemistry with up to 3 years industry experience
- Understanding of the scientific principles, processes, and concepts of drug discovery
- Strong technical and synthetic background as demonstrated through publication of peer-reviewed journal articles and/or relevant patents
- Clear and concise communication skills
$110,000 - $150,000 a year
Target Bonus: 1o-15%
Exact compensation may vary based on skills, experience, and location.
Our Locations Waltham, MA: Our Boston office includes an open office layout that has recently undergone a makeover designed for collaboration and giving our employees the best work place possible. Free access is provided for both on-site parking and gym facilities in the building.
Boulder, CO: We have just moved into our new state-of-the art Research Facility in the fast-growing biopharmaceutical hub in the greater Denver/Boulder corridor. Our CEO is based full-time in this location and we are proud to call this the home of Cogent's discovery research organization.
Our Offer To You To attract the very best talent, we offer a generous benefits package that includes competitive pay, performance-based bonus, stock options, insurance coverage (health, dental, life, and disability), competitive time-off, a 401(k) plan, and commuter/parking benefits.
We are proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability, or any other status protected under federal, state, or local law. All employment is decided on the basis of qualifications, merit, and business need.
Job Tags
Full time, Local area,